Article
Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
Cancer science - 1 Jul 2013
Suzuki Makito, Makinoshima Hideki, Matsumoto Shingo, Suzuki Ayako, Mimaki Sachiyo, Matsushima Koutatsu, Yoh Kiyotaka, Goto Koichi, Suzuki Yutaka, Ishii Genichiro, Ochiai Atsushi, Tsuta Koji, Shibata Tatsuhiro, Kohno Takashi, Esumi Hiroyasu, Tsuchihara Katsuya
Abstract excerpt
Rearrangements of the proto-oncogene RET are newly identified potential driver mutations in lung adenocarcinoma (LAD). However, the absence of cell lines harboring RET fusion genes has hampered the investigation of the biological relevance of RET and the development of RET-targeted therapy. Thus, we aimed to identify a RET fusion positive LAD cell line. Eleven LAD cell lines were screened for RET fusion...
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