Article
The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.
Development (Cambridge, England) - 1 Apr 2014
Mahbub Hasan A K M, Hashimoto Aki, Maekawa Yuka, Matsumoto Takashi, Kushima Shota, Ijiri Takashi W, Fukami Yasuo, Sato Ken-ichi
Abstract excerpt
In Xenopus laevis, sperm-egg interaction promotes partial proteolysis and/or tyrosine phosphorylation of uroplakin III (UPIII) and the tyrosine kinase Src, which both localize to the cholesterol-enriched egg membrane microdomains (MDs). Here we show that sperm promote proteolysis and/or tyrosine phosphorylation of UPIII and Src in MDs isolated from ovulated and unfertilized eggs (UF-MDs). An antibody against the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.