Article
The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression.
Carcinogenesis - 1 Aug 2014
Balabanova Silvia, Holmberg Chris, Steele Islay, Ebrahimi Bahram, Rainbow Lucille, Burdyga Ted, McCaig Cathy, Tiszlavicz Lazso, Lertkowit Nantaporn, Giger Olivier T, Oliver Simon, Prior Ian, Dimaline Rod, Simpson Deborah, Beynon Rob, Hegyi Peter, Wang Timothy C, Dockray Graham J, Varro Andrea
Abstract excerpt
Stromal cells influence cancer progression. Myofibroblasts are an important stromal cell type, which influence the tumour microenvironment by release of extracellular matrix (ECM) proteins, proteases, cytokines and chemokines. The mechanisms of secretion are poorly understood. Here, we describe the secretion of marker proteins in gastric cancer and control myofibroblasts in response to insulin-like growth factor...
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