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Identification of differentially expressed proteins in colorectal cancer by proteomics: Down‐regulation of secretagogin

3 Apr 2006

Abstract excerpt

To identify proteins with colorectal cancer-specific regulation, comparative 2-DE of individual-matched normal and neoplastic colorectal tissue specimens was performed. We found 15 protein spots with concordantly increased and 20 protein spots with concordantly decreased intensity in tumor tissue (expression regulation more than fivefold). Nine of these proteins were identified by MS/MS. Interestingly, one of the...

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PMID: 16586428
DOI: 10.1002/pmic.200401355

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