Article
Identifying regulatory mechanisms underlying tumorigenesis using locus expression signature analysis.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2014
Lee Eunjee, de Ridder Jeroen, Kool Jaap, Wessels Lodewyk F A, Bussemaker Harmen J
Abstract excerpt
Retroviral insertional mutagenesis is a powerful tool for identifying putative cancer genes in mice. To uncover the regulatory mechanisms by which common insertion loci affect downstream processes, we supplemented genotyping data with genome-wide mRNA expression profiling data for 97 tumors induced by retroviral insertional mutagenesis. We developed locus expression signature analysis, an algorithm to construct...
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