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Article

Modulation of HBV replication by microRNA-15b through targeting hepatocyte nuclear factor 1α

4 Apr 2014

Abstract excerpt

Hepatitis B virus (HBV) infection remains a major health problem worldwide. The role played by microRNAs (miRNAs) in HBV replication and pathogenesis is being increasingly recognized. In this study, we found that miR-15b, an important miRNA during HBV infection and hepatocellular carcinoma development, directly binds hepatocyte nuclear factor 1α (HNF1α) mRNA, a negative regulator of HBV Enhancer I, to attenuate...

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PMID: 24705650
DOI: 10.1093/nar/gku260

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