Article
Vitamin D receptor polymorphism FokI is associated with spontaneous idiopathic preterm birth in an Israeli population.
European journal of obstetrics, gynecology, and reproductive biology - 1 Jun 2014
Manzon Lauren, Altarescu Gheona, Tevet Aharon, Schimmel Michael S, Elstein Deborah, Samueloff Arnon, Grisaru-Granovsky Sorina
Abstract excerpt
OBJECTIVE: The active form of vitamin D (1,25[OH]2D3) has been established to have potent anti-proliferative, immuno-modulatory, and anti-microbial action in addition to its effects on bone. The nuclear vitamin D receptor (VDR) is expressed in the placenta-decidua, regulating genes associated with implantation and implantation immuno-tolerance. If VDR polymorphisms regulate VDR functionality at the...
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