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Article

Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence.

The Journal of biological chemistry - 2 Nov 2012

Maes Michal, Rimon Abraham, Kozachkov-Magrisso Lena, Friedler Assaf, Padan Etana

Abstract excerpt

pH and Na(+) homeostasis in all cells requires Na(+)/H(+) antiporters. In most cases, their activity is tightly pH-regulated. NhaA, the main antiporter of Escherichia coli, has homologues in all biological kingdoms. The crystal structure of NhaA provided insights into the mechanism of action and pH regulation of an antiporter. However, the active site of NhaA remained elusive because neither Na(+) nor Li(+), the...

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Identifiers

PMID: 22915592
DOI: 10.1074/jbc.M112.391128
PMCID: PMC3488084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence.PMID 22915592Read ↗

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