Article
V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.
Neuron - 2 Apr 2014
Zhang Jingming, Lanuza Guillermo M, Britz Olivier, Wang Zhi, Siembab Valerie C, Zhang Ying, Velasquez Tomoko, Alvarez Francisco J, Frank Eric, Goulding Martyn
Abstract excerpt
Reciprocal activation of flexor and extensor muscles constitutes the fundamental mechanism that tetrapod vertebrates use for locomotion and limb-driven reflex behaviors. This aspect of motor coordination is controlled by inhibitory neurons in the spinal cord; however, the identity of the spinal interneurons that serve this function is not known. Here, we show that the production of an alternating flexor-extensor...
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