Article
Development of a high-resolution melting genotyping assay for the angiotensin I converting enzyme insertion/deletion polymorphism and establishment of genotype-specific reference intervals in a Danish population.
Annals of clinical biochemistry - 1 Jan 2015
Nissen Peter H, Campbell Nina Buntzen, Højskov Carsten S, Fløe Andreas, Hoffmann Hans Jürgen, Hilberg Ole, Ladefoged Søren A, Møller Holger J
Abstract excerpt
BACKGROUND: The serum-angiotensin I converting enzyme (s-ACE) activity is influenced by a genetic insertion/deletion (I/D) polymorphism in the ACE gene, and the resulting large interindividual variation in s-ACE limits the use of normal reference intervals in the evaluation of sarcoidosis. In this study, we developed a new method for genotyping the I/D polymorphism in ACE and established genotype-specific...
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