Article
[Corrected normal values for serum ACE by genotyping the deletion-/insertion-polymorphism of the ACE gene].
Pneumologie (Stuttgart, Germany) - 1 Jul 2001
Ruprecht B, Schürmann M, Ziegenhagen M W, vom Bauer E, Meier D, Schlaak M, Müller-Quernheim J
Abstract excerpt
BACKGROUND: In sarcoidosis, serum ACE is widely recognised as a marker of disease activity. Since 1990 a deletion-/insertion polymorphism of the ACE gene is known and a correlation between the genotypes of this polymorphism and serum ACE levels has been observed. Homzygotes for the deletion allele (DD) have the highest levels and homozygotes for the insertion allele (II) the lowest. Heterozygote (DI) persons show...
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