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Article

Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster.

Neurobiology of disease - 1 Jul 2014

Murali A, Maue R A, Dolph P J

Abstract excerpt

Prion diseases are progressive disorders that affect the central nervous system leading to memory loss, personality changes, ataxia and neurodegeneration. In humans, these disorders include Creutzfeldt-Jakob disease, kuru and Gerstmann-Straüssler-Scheinker (GSS) syndrome, the latter being a dominantly inherited prion disease associated with missense mutations in the gene that codes for the prion protein. The...

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Identifiers

PMID: 24686303
DOI: 10.1016/j.nbd.2014.03.013

Genes

GSS

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