Article
Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice.
PloS one - 1 Jan 2014
Wu Haiya, Yang Jun, Su Emily M, Li Ling, Zhao Caiqi, Yang Xi, Gao Zhaowei, Pan Mengyao, Sun Peiyu, Sun Wei, Jiang Yiyi, Su Xiao
Abstract excerpt
CFTR (cystic fibrosis transmembrane conductance regulator) is expressed by both neutrophils and platelets. Lack of functional CFTR could lead to severe lung infection and inflammation. Here, we found that mutation of CFTR (F508del) or inhibition of CFTR in mice led to more severe thrombocytopenia...
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