Article
A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE).
Database : the journal of biological databases and curation - 1 Jan 2014
Wu Tsung-Jung, Shamsaddini Amirhossein, Pan Yang, Smith Krista, Crichton Daniel J, Simonyan Vahan, Mazumder Raja
Abstract excerpt
Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq and other database biocurators has led to a rich repository of information on functional sites of genes and proteins. This information along with variation-related annotation can be used to scan human short sequence reads from next-generation sequencing (NGS) pipelines for presence of non-synonymous single-nucleotide variations...
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