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T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis

12 Nov 2013

Abstract excerpt

Appendicitis followed by appendectomy (AA) at a young age protects against inflammatory bowel disease (IBD). We wanted to characterize the role of the T helper type 17 (Th17) system involved in this protective effect. AA was performed on 5-week-old male BALB/c mice and distal-colon samples were harvested. Mice with two laparotomies each served as sham-sham (SS) controls. RNA was extracted from four individual...

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PMID: 24666024
DOI: 10.1111/cei.12237

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