Article
Effective variant detection by targeted deep sequencing of DNA pools: an example from Parkinson's disease.
Annals of human genetics - 1 May 2014
Pihlstrøm Lasse, Rengmark Aina, Bjørnarå Kari Anne, Toft Mathias
Abstract excerpt
Next-generation sequencing technologies will dominate the next phase of discoveries in human genetics, but considerable costs may still represent a limitation for studies involving large sample sets. Targeted capture of genomic regions may be combined with deep sequencing of DNA pools to efficiently screen sample cohorts for disease-relevant mutations. We designed a 200 kb HaloPlex kit for PCR-based capture of...
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