Article
Next-Generation Sequencing Approaches to Define the Role of the Autophagy Lysosomal Pathway in Human Disease: The Example of LysoPlex.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Di Fruscio Giuseppina, Banfi Sandro, Nigro Vincenzo, Ballabio Andrea
Abstract excerpt
Next-Generation Sequencing (NGS) technologies have deeply changed the throughput of genetic testing allowing analyzing millions of DNA fragments in parallel. One key application is the understanding of genetically heterogeneous and complex diseases where 50-100 different genes may converge to control the same pathways. These disorders cannot be studied using traditional approaches, based on gene-by-gene Sanger...
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