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Article

The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning.

Psychology and aging - 1 Jun 2014

Ferencz Beata, Laukka Erika J, Welmer Anna-Karin, Kalpouzos Grégoria, Angleman Sara, Keller Lina, Graff Caroline, Lövdén Martin, Bäckman Lars

Abstract excerpt

PICALM, BIN1, CLU, and APOE are top candidate genes for Alzheimer's disease, and they influence episodic memory performance in old age. Physical activity, however, has been shown to protect against age-related decline and counteract genetic influences on cognition. The aims of this study were to assess whether (a) a genetic risk constellation of PICALM, BIN1, and CLU polymorphisms influences cognitive performance...

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Source

Identifiers

PMID: 24660791
DOI: 10.1037/a0035465

Genes

BIN1
CLU
PICALM
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning.PMID 24660791Read ↗

Association of genetic risk factors with cognitive decline: the PATH through life project.Semantic proximity Read ↗

Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.Semantic proximity Read ↗

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Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementiaSemantic proximity Read ↗

Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK BiobankSemantic proximity Read ↗

Genetic effects on old-age cognitive functioning: a population-based study.Semantic proximity Read ↗

How does Apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative modelSemantic proximity Read ↗

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Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia.Semantic proximity Read ↗

How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.Semantic proximity Read ↗

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