Antitumor and immunomodulatory effects of low-dose 5-FU on hepatoma 22 tumor-bearing mice

Abstract excerpt

Low‑dose 5‑fluorouracil (5‑FU), a widely used chemotherapeutic, has been reported to have immunomodulatory effects. This study aimed to evaluate the optimal dose of 5‑FU that produces antitumor and immunomodulatory effects. In a hepatoma 22 tumor‑bearing mouse model, 0, 10, 20 and 40 mg/kg 5‑FU (i.p.) was administered for 10 days. Tumor weight and volume were measured, thymus index (TI) and spleen index (SI) were...

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