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Article

The Protective Effect of Silibinin Against Mitomycin C–Induced Intrinsic Apoptosis in Human Melanoma A375-S2 Cells

1 Jan 2009

Abstract excerpt

Silibinin is known for its hepatoprotective, anti-inflammatory, and anti-carcinogenic effects. We found that silibinin exhibited a protective effect against chemotherapeutic reagent mitomycin C-induced cell death in A375-S2 cells in a p53-dependent manner, which contradicted the findings of previous studies investigating the anti-neoplastic activity of silibinin and developing silibinin as a potential...

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PMID: 19834285
DOI: 10.1254/jphs.09171fp

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