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Article

Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.

American journal of respiratory cell and molecular biology - 1 Aug 2011

Tu Ly, Dewachter Laurence, Gore Benoit, Fadel Elie, Dartevelle Philippe, Simonneau Gérald, Humbert Marc, Eddahibi Saadia, Guignabert Christophe

Abstract excerpt

Pulmonary vascular remodeling is key to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). We recently reported that fibroblast growth factor (FGF)2 is markedly overproduced by pulmonary endothelial cells (P-ECs) in IPAH and contributes significantly to smooth muscle hyperplasia and disease progression. Excessive FGF2 expression in malignancy exerts pathologic effects on tumor cells by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21037114
DOI: 10.1165/rcmb.2010-0317OC
PMCID: PMC4834126

Genes

FGF2
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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