Article
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
Heart rhythm - 1 Mar 2013
Noorman Maartje, Hakim Sara, Kessler Elise, Groeneweg Judith A, Cox Moniek G P J, Asimaki Angeliki, van Rijen Harold V M, van Stuijvenberg Leonie, Chkourko Halina, van der Heyden Marcel A G, Vos Marc A, de Jonge Nicolaas, van der Smagt Jasper J, Dooijes Dennis, Vink Aryan, de Weger Roel A, Varro Andras, de Bakker Jacques M T, Saffitz Jeffrey E, Hund Thomas J, Mohler Peter J, Delmar Mario, Hauer Richard N W, van Veen Toon A B
Abstract excerpt
BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is closely associated with desmosomal mutations in a majority of patients. Arrhythmogenesis in patients with AC is likely related to remodeling of cardiac gap junctions and increased levels of fibrosis. Recently, using experimental models, we also identified sodium channel dysfunction secondary to desmosomal dysfunction. OBJECTIVE: To assess the immunoreactive signal...
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