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Article

Development of oseltamivir phosphonate congeners as anti-influenza agents.

Journal of medicinal chemistry - 25 Oct 2012

Cheng Ting-Jen R, Weinheimer Steven, Tarbet E Bart, Jan Jia-Tsrong, Cheng Yih-Shyun E, Shie Jiun-Jie, Chen Chun-Lin, Chen Chih-An, Hsieh Wei-Che, Huang Pei-Wei, Lin Wen-Hao, Wang Shi-Yun, Fang Jim-Min, Hu Oliver Yoa-Pu, Wong Chi-Huey

Abstract excerpt

Oseltamivir phosphonic acid (tamiphosphor, 3a), its monoethyl ester (3c), guanidino-tamiphosphor (4a), and its monoethyl ester (4c) are potent inhibitors of influenza neuraminidases. They inhibit the replication of influenza viruses, including the oseltamivir-resistant H275Y strain, at low nanomolar to picomolar levels, and significantly protect mice from infection with lethal doses of influenza viruses when...

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Identifiers

PMID: 23009169
DOI: 10.1021/jm3008486
PMCID: PMC3492761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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