Article
Telomere length shows no association with BRCA1 and BRCA2 mutation status.
PloS one - 1 Jan 2014
Killick Emma, Tymrakiewicz Malgorzata, Cieza-Borrella Clara, Smith Paula, Thompson Deborah J, Pooley Karen A, Easton Doug F, Bancroft Elizabeth, Page Elizabeth, Leongamornlert Daniel, Kote-Jarai Zsofia, Eeles Rosalind A
Abstract excerpt
This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrollment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group...
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