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Article

Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma

16 Mar 2014

Abstract excerpt

BACKGROUND: Glioblastoma subtypes have been defined based on transcriptional profiling, yet personalized care based on molecular classification remains unexploited. Topoisomerase II (TOP2) contributes to the transcriptional signature of the proneural glioma subtype. Thus, we targeted TOP2 pharmacologically with etoposide in proneural glioma models. METHODS: TOP2 gene expression was evaluated in mouse platelet...

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PMID: 24637229
DOI: 10.1093/neuonc/nou026

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