Article
Lethality of visible light for Escherichia coli hemH1 mutants influence of defects in DNA repair.
DNA repair - 2 Jan 2003
Sikora Anna, Grzesiuk Elzbieta, Zbieć Renata, Janion Celina
Abstract excerpt
The hemH gene encodes ferrochelatase, the final enzyme of the heme biosynthetic pathway. Defects of this enzyme lead to accumulation of protoporphyrin IX and an increase in reactive oxygen species, causing susceptibility to blue and white light in bacteria and protoporphyria in humans. Here we show that the photosensitivity of hemH1 strains is much increased when the bacteria are devoid of ability to repair...
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