Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant.

doi:10.1016/j.intimp.2014.02.035

Article

Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant.

International immunopharmacology - 1 May 2014

Funakoshi-Tago Megumi, Tsukada Masaki, Watanabe Toshiro, Mameda Yuka, Tago Kenji, Ohe Tomoyuki, Nakamura Shigeo, Mashino Tadahiko, Kasahara Tadashi

Abstract excerpt

JAK2 V617F mutant, a gene responsible for human myeloproliferative neoplasms (MPNs), causes not only cellular transformation but also resistance to various anti-cancer drugs. We previously reported that pyrrolidinium fullerene markedly induced the apoptosis of JAK2 V617F mutant-induced transformed cells through the reduction of apoptosis signal-regulating kinase 1 (ASK1), following inhibition of the c-Jun...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant.

Abstract excerpt

Topics

Related research