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Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration

22 Oct 2014

Abstract excerpt

Viruses are the causative agents of 10%-15% of human cancers worldwide. The most common outcome for virus-induced reprogramming is genomic instability, including accumulation of mutations, aberrations and DNA damage. Although each virus has its own specific mechanism for promoting carcinogenesis, the majority of DNA oncogenic viruses encode oncogenes that transform infected cells, frequently by targeting p53 and...

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PMID: 25340830
DOI: 10.3390/cancers6042155

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