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Article

Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 Family

14 Mar 2014

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is required for the specification of tissues during embryonic development and is recapitulated during the metastatic progression of tumors. The miR-200 family plays a critical role in enforcing the epithelial state with their expression lost in cells undergoing EMT. EMT can be mediated by activation of the ZEB1 and ZEB2 (ZEB) transcription factors, which repress miR-200...

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PMID: 24627491
DOI: 10.1074/jbc.m113.529172

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