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Article

miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.

Nature communications - 27 Oct 2017

Diepenbruck Maren, Tiede Stefanie, Saxena Meera, Ivanek Robert, Kalathur Ravi Kiran Reddy, Lüönd Fabiana, Meyer-Schaller Nathalie, Christofori Gerhard

Abstract excerpt

Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial-mesenchymal transition. Transcriptional regulators and post-transcriptional effectors like microRNAs orchestrate this process of high cellular plasticity and its malignant consequences. Here, using microRNA sequencing in a time-resolved manner and functional validation, we have identified microRNAs that are critical...

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Cell Movement
Down-Regulation
Epithelial-Mesenchymal Transition
Mammary Neoplasms, Animal
MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Transforming Growth Factor beta

Zinc Finger E-box-Binding Homeobox 1

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Identifiers

PMID: 29079737
DOI: 10.1038/s41467-017-01197-w
PMCID: PMC5660124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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