Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage.

doi:10.1093/hmg/ddu118

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Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage.

Human molecular genetics - 1 Aug 2014

Barfield Whitney L, Uaesoontrachoon Kitipong, Wu Chung-Sheih, Lin Stephen, Chen Yue, Wang Paul C, Kanaan Yasmine, Bond Vernon, Hoffman Eric P

Abstract excerpt

A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated with multiple inflammatory states, severity of Duchenne muscular dystrophy (DMD) and muscle size in healthy young adults. We sought to define the mechanism of action of the polymorphism, using allele-specific in vitro reporter assays in muscle cells, and a genotype-stratified intervention in healthy controls. In vitro reporter...

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PMID: 24626632
DOI: 10.1093/hmg/ddu118
PMCID: PMC4082368

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