Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy.

doi:10.1212/WNL.0b013e31825f04ea

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Article

Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy.

Neurology - 10 Jul 2012

Bello Luca, Piva Luisa, Barp Andrea, Taglia Antonella, Picillo Esther, Vasco Gessica, Pane Marika, Previtali Stefano C, Torrente Yvan, Gazzerro Elisabetta, Motta Maria Chiara, Grieco Gaetano S, Napolitano Sara, Magri Francesca, D'Amico Adele, Astrea Guja, Messina Sonia, Sframeli Maria, Vita Gian Luca, Boffi Patrizia, Mongini Tiziana, Ferlini Alessandra, Gualandi Francesca, Soraru' Gianni, Ermani Mario, Vita Giuseppe, Battini Roberta, Bertini Enrico, Comi Giacomo P, Berardinelli Angela, Minetti Carlo, Bruno Claudio, Mercuri Eugenio, Politano Luisa, Angelini Corrado, Hoffman Eric P, Pegoraro Elena

Abstract excerpt

OBJECTIVE: To test the effect of the single nucleotide polymorphism -66 T>G (rs28357094) in the osteopontin gene (SPP1) on functional measures over 12 months in Duchenne muscular dystrophy (DMD). METHODS: This study was conducted on a cohort of ambulatory patients with DMD from a network of Italian neuromuscular centers, evaluated longitudinally with the north star ambulatory assessment (NSAA) and the 6-minute...

Topics

Adolescent
Adult
Child
Child, Preschool
Clinical Trials as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Longitudinal Studies

Multicenter Studies as Topic

Muscular Dystrophy, Duchenne

Osteopontin

Polymorphism, Single Nucleotide

Retrospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 22744661
DOI: 10.1212/WNL.0b013e31825f04ea
PMCID: PMC3390537

Genes

DMD
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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