Alterations in osteopontin modify muscle size in females in both humans and mice.

doi:10.1249/MSS.0b013e31828093c1

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Article

Alterations in osteopontin modify muscle size in females in both humans and mice.

Medicine and science in sports and exercise - 1 Jun 2013

Hoffman Eric P, Gordish-Dressman Heather, McLane Virginia D, Devaney Joseph M, Thompson Paul D, Visich Paul, Gordon Paul M, Pescatello Linda S, Zoeller Robert F, Moyna Niall M, Angelopoulos Theodore J, Pegoraro Elena, Cox Gregory A, Clarkson Priscilla M

Abstract excerpt

PURPOSE: An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers. METHODS: Gene association studies were carried out for OPN (rs28357094) in the FAMuSS cohort (n = 752; mean ± SD age = 23.7 ± 5.7 yr). The phenotypes studied included muscle size (MRI), strength, and response...

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PMID: 23274598
DOI: 10.1249/MSS.0b013e31828093c1
PMCID: PMC3631433

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SPP1

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