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Article

Polygenic mechanisms underpinning the response to exercise-induced muscle damage in humans: In vivo and in vitro evidence.

Journal of cellular physiology - 1 Jul 2022

Baumert Philipp, Cocks Matthew, Strauss Juliette A, Shepherd Sam O, Drust Barry, Lake Mark J, Stewart Claire E, Erskine Robert M

Abstract excerpt

We investigated whether 20 candidate single nucleotide polymorphisms (SNPs) were associated with in vivo exercise-induced muscle damage (EIMD), and with an in vitro skeletal muscle stem cell wound healing assay. Sixty-five young, untrained Caucasian adults performed 120 maximal eccentric knee-extensions on an isokinetic dynamometer to induce EIMD. Maximal voluntary isometric/isokinetic knee-extensor torque, knee...

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PMID: 35312042
DOI: 10.1002/jcp.30723

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