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Article

p53 haploinsufficiency and functional abnormalities in multiple myeloma.

Leukemia - 1 Oct 2014

Teoh P J, Chung T H, Sebastian S, Choo S N, Yan J, Ng S B, Fonseca R, Chng W J

Abstract excerpt

Hemizygous deletion of 17p13, which harbors the TP53 gene, has been identified in >10% of newly diagnosed multiple myeloma (MM) patients and is associated with poor prognosis. To date, there is no conclusive evidence that TP53 is the critical gene. Furthermore, the functional effect of TP53 haploinsufficiency is not well characterized. By utilizing human myeloma cell lines, we showed that TP53 hemizygous loss was...

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Share to Genes, p53
Share to Cell Survival
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to DNA Methylation

Share to Gene Silencing

Share to Haploinsufficiency

Share to Multiple Myeloma

Source

Identifiers

PMID: 24625551
DOI: 10.1038/leu.2014.102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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