Article
The clinical impact and molecular biology of del(17p) in multiple myeloma treated with conventional or thalidomide-based therapy.
Genes, chromosomes & cancer - 1 Oct 2011
Boyd Kevin D, Ross Fiona M, Tapper William J, Chiecchio Laura, Dagrada GianPaolo, Konn Zoe J, Gonzalez David, Walker Brian A, Hockley Sarah L, Wardell Christopher P, Gregory Walter M, Child J Anthony, Jackson Graham H, Davies Faith E, Morgan Gareth J
Abstract excerpt
Hemizygous deletion of 17p (del(17p)) has been identified as a variable associated with poor prognosis in myeloma, although its impact in the context of thalidomide therapy is not well described. The clinical outcome of 85 myeloma patients with del(17p) treated in a clinical trial incorporating both conventional and thalidomide-based induction therapies was examined. The clinical impact of deletion, low...
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