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Article

Smoking and risk of multiple sclerosis: evidence of modification by NAT1 variants.

Epidemiology (Cambridge, Mass.) - 1 Jul 2014

Briggs Farren B S, Acuna Brigid, Shen Ling, Ramsay Patricia, Quach Hong, Bernstein Allan, Bellesis Kalliope H, Kockum Ingrid S, Hedström Anna K, Alfredsson Lars, Olsson Tomas, Schaefer Catherine, Barcellos Lisa F

Abstract excerpt

BACKGROUND: Tobacco smoke is an established risk factor for multiple sclerosis (MS). We hypothesized that variation in genes involved in metabolism of tobacco smoke constituents may modify MS risk in smokers. METHODS: A three-stage gene-environment investigation was conducted for NAT1, NAT2, and GSTP1 variants. The discovery analysis was conducted among 1588 white MS cases and controls from the Kaiser Permanente...

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Identifiers

PMID: 24625537
DOI: 10.1097/EDE.0000000000000089

Genes

NAT1
GSTP1
NAT2

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