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Article

A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA.

Rapid communications in mass spectrometry : RCM - 30 Apr 2014

Trim Paul J, Lau Adeline A, Hopwood John J, Snel Marten F

Abstract excerpt

RATIONALE: Determination of genotype can be difficult, especially during the early stages of developing an animal model, e.g. when PCR primers are not yet available. An increase or decrease in specific metabolites can be used as a surrogate marker for genotype; for instance, in homozygous MPS IIIA mice heparan sulphate (HS) is increased. METHODS: A simple method was developed for extracting and depolymerising HS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24623698
DOI: 10.1002/rcm.6861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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