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Article

Functional characterization of ocular-derived human alphaherpesvirus cross-reactive CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014

Ouwendijk Werner J D, Geluk Annemieke, Smits Saskia L, Getu Sarah, Osterhaus Albert D M E, Verjans Georges M G M

Abstract excerpt

Intraocular varicella-zoster virus (VZV) and HSV type 1 (HSV-1) infections cause sight-threatening uveitis. The disease is characterized by an intraocular inflammatory response involving herpesvirus-specific T cells. T cell reactivity to the noncausative human alphaherpesvirus (αHHV) is commonly detected in the affected eyes of herpetic uveitis patients, suggesting the role of cross-reactive T cells in the...

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PMID: 24623134
DOI: 10.4049/jimmunol.1302307

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RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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