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Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

1 Apr 2024

Abstract excerpt

The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against varicella-zoster virus (VZV) influences the risk of HZ. We show that CD4 + T cell TCR diversity against VZV glycoprotein E (gE) and immediate early 63 protein (IE63)...

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PMID: 38588339
DOI: 10.1016/j.celrep.2024.114062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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