Article
Prevalence of Staphylococcus aureus protein A (spa) mutants in the community and hospitals in Oxfordshire.
BMC microbiology - 12 Mar 2014
Votintseva Antonina A, Fung Rowena, Miller Ruth R, Knox Kyle, Godwin Heather, Wyllie David H, Bowden Rory, Crook Derrick W, Walker A Sarah
Abstract excerpt
BACKGROUND: Staphylococcal protein A (spa) is an important virulence factor which enables Staphylococcus aureus to evade host immune responses. Genotypes known as "spa-types", based on highly variable Xr region sequences of the spa-gene, are frequently used to classify strains. A weakness of current spa-typing primers is that rearrangements in the IgG-binding region of the gene cause 1-2% of strains to be...
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