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Increased Dentate Neurogenesis After Grafting of Glial Restricted Progenitors or Neural Stem Cells in the Aging Hippocampus

17 May 2007

Abstract excerpt

Neurogenesis in the dentate gyrus (DG) declines severely by middle age, potentially because of age-related changes in the DG microenvironment. We hypothesize that providing fresh glial restricted progenitors (GRPs) or neural stem cells (NSCs) to the aging hippocampus via grafting enriches the DG microenvironment and thereby stimulates the production of new granule cells from endogenous NSCs. The GRPs isolated...

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PMID: 17510219
DOI: 10.1634/stemcells.2006-0726

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