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Article

The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age.

PLoS genetics - 1 Mar 2014

MacArthur Jacqueline A L, Spector Timothy D, Lindsay Sarah J, Mangino Massimo, Gill Raj, Small Kerrin S, Hurles Matthew E

Abstract excerpt

Nonallelic homologous recombination (NAHR) between highly similar duplicated sequences generates chromosomal deletions, duplications and inversions, which can cause diverse genetic disorders. Little is known about interindividual variation in NAHR rates and the factors that influence this. We estimated the rate of deletion at the CMT1A-REP NAHR hotspot in sperm DNA from 34 male donors, including 16 monozygotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24603440
DOI: 10.1371/journal.pgen.1004195
PMCID: PMC3945173

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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