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Article

Testing the key assumption of heritability estimates based on genome-wide genetic relatedness.

Journal of human genetics - 1 Jun 2014

Conley Dalton, Siegal Mark L, Domingue Benjamin W, Mullan Harris Kathleen, McQueen Matthew B, Boardman Jason D

Abstract excerpt

Comparing genetic and phenotypic similarity among unrelated individuals seems a promising way to quantify the genetic component of traits while avoiding the problematic assumptions plaguing twin- and other kin-based estimates of heritability. One approach uses a Genetic Relatedness Estimation through Maximum Likelihood (GREML) model for individuals who are related at less than 0.025 to predict their phenotypic...

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Identifiers

PMID: 24599117
DOI: 10.1038/jhg.2014.14
PMCID: PMC4126504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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