Article
Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro.
Toxicology letters - 2 May 2014
Chen Zhangjian, Wang Yun, Ba Te, Li Yang, Pu Ji, Chen Tian, Song Yanshuang, Gu Yongen, Qian Qin, Yang Jinglin, Jia Guang
Abstract excerpt
With the extensive application of titanium dioxide (TiO2) nanoparticles (NPs) in food industry, there is a rising debate concerning the possible risk associated with exposure to TiO2 NPs. The purpose of this study is to evaluate the genotoxicity of TiO2 NPs using in vivo and in vitro test systems. In vivo study, the adult male Sprague-Dawley rats were exposed to anatase TiO2 NPs (75 ± 15 nm) through intragastric...
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