Article
Consensus HIV-1 subtype A integrase and its raltegravir-resistant variants: design and characterization of the enzymatic properties.
Biochimie - 1 Jul 2014
Shadrina Olga, Krotova Olga, Agapkina Julia, Knyazhanskaya Ekaterina, Korolev Sergey, Starodubova Elizaveta, Viklund Alecia, Lukashov Vladimir, Magnani Mauro, Medstrand Patrik, Karpov Vadim, Gottikh Marina, Isaguliants Maria
Abstract excerpt
Model studies of the subtype B and non-subtype B integrases are still required to compare their susceptibility to antiretroviral drugs, evaluate the significance of resistance mutations and identify the impact of natural polymorphisms on the level of enzymatic reactivity. We have therefore designed the consensus integrase of the HIV-1 subtype A strain circulating in the former Soviet Union territory (FSU-A) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.