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Article

Hypoxia in Leishmania major skin lesions impairs the NO-dependent leishmanicidal activity of macrophages.

The Journal of investigative dermatology - 1 Sept 2014

Mahnke Alexander, Meier Robert J, Schatz Valentin, Hofmann Julian, Castiglione Kirstin, Schleicher Ulrike, Wolfbeis Otto S, Bogdan Christian, Jantsch Jonathan

Abstract excerpt

Cure of infections with Leishmania major is critically dependent on the ability of macrophages to induce the type 2 nitic oxide (NO) synthase (NOS2) that produces high levels of NO in the presence of ample oxygen. Therefore, we analyzed the oxygen levels found in leishmanial skin lesions and their effect on the NOS2-dependent leishmanicidal activity of macrophages (MΦ). When L. major skin lesions of self-healing...

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Identifiers

PMID: 24583949
DOI: 10.1038/jid.2014.121

Genes

NOS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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