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Access and utilization of host-derived iron by Leishmania parasites

13 Oct 2023

Abstract excerpt

Iron is involved in many biochemical processes including oxygen transport, ATP production, DNA synthesis and antioxidant defense. The importance of iron also applies to Leishmania parasites, an intracellular protozoan pathogen causing leishmaniasis. Leishmania are heme-auxotrophs, devoid of iron storage proteins and the heme synthesis pathway. Acquisition of iron and heme from the surrounding niche is thus...

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PMID: 37830941
DOI: 10.1093/jb/mvad082

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