Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.

Abstract excerpt

It is often assumed that Mycobacterium tuberculosis (Mtb)-induced granulomatous lesions, particularly those undergoing central caseation, are anoxic, and that the survival of Mtb in these lesions requires the integrity of its non-oxidative respiratory pathways. Using the hypoxia marker pimonidazole, we now provide immunohistochemical evidence that in the most frequently used animal model system of inbred mice...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Electrodes
• Share to Granuloma
• Share to Hypoxia