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Article

Light damage in Abca4 and Rpe65rd12 mice.

Investigative ophthalmology & visual science - 28 Mar 2014

Wu Li, Ueda Keiko, Nagasaki Taka, Sparrow Janet R

Abstract excerpt

PURPOSE: Bisretinoids form in photoreceptor cells and accumulate in retinal pigment epithelium (RPE) as lipofuscin. To examine the role of these fluorophores as mediators of retinal light damage, we studied the propensity for light damage in mutant mice having elevated lipofuscin due to deficiency in the ATP-binding cassette (ABC) transporter Abca4 (Abca4(-/-) mice) and in mice devoid of lipofuscin owing to...

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Share to ATP-Binding Cassette Transporters
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24576873
DOI: 10.1167/iovs.14-13867
PMCID: PMC3973190

Genes

RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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